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KMID : 0371420231050030141
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Annals of Surgical Treatment and Research
2023 Volume.105 No. 3 p.141 ~ p.147
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Ventilator support in the pretransplant period predisposes early graft failure after deceased donor liver transplantation
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Lee Nu-Ri
Cha So-Ra
Kim Jong-Man
Lee Yun-Mi
Kang En-Jin
Kim Hyun-Jung
Hong Seung-Hui
Rhu Jin-Soo
Choi Gyu-Seong
Joh Jae-Won
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Abstract
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Purpose : Deceased donor liver transplantation (DDLT) recipients in Korea are generally sicker due to an increasing organ shortage. In the present study, the risk factors for early 30-day liver graft failure after DDLT were identified.
Methods : From August 2017 to February 2021, 265 adult DDLTs were performed. The characteristics of patients with and without 30-day graft failure were compared.
Results : Liver graft failure occurred in 11 patients (17.7%) after DDLT. Baseline and perioperative characteristics of donors and recipients were not statistically significantly different between the 2 groups. The cumulative graft and overall survival rates at 6 months were 83.9% and 88.7%, respectively. Multivariate analysis showed ventilator support in the pretransplant period was a predisposing factor for 30-day graft failure after DDLT.
Conclusion : Present study indicates that cautious decision is required when allocating DDLT in critically ill patients on mechanical ventilatory support.
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KEYWORD
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Brain death donor, Delayed graft function, Liver regeneration, Mechanical ventilator, Primary graft dysfunction
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